Article
Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer.
The Journal of pathology - 1 Feb 2001
Park W S, Oh R R, Kim Y S, Park J Y, Lee S H, Shin M S, Kim S Y, Kim P J, Lee H K, Yoo N Y, Lee J Y
Abstract excerpt
It is now believed that genes regulating apoptosis are also important variables in cancer development. Fas, a transmembrane protein of the tumour necrosis factor receptor family, is a key molecule for cell death signalling. The mutation of the primary structure of the Fas gene might also be one of the possible mechanisms that disrupt Fas-mediated apoptosis in tumour cells. The purpose of this study was to...
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