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Article

Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases.

PloS one - 1 Jan 2013

Hashemi Mohammad, Fazaeli Aliakbar, Ghavami Saeid, Eskandari-Nasab Ebrahim, Arbabi Farshid, Mashhadi Mohammad Ali, Taheri Mohsen, Chaabane Wiem, Jain Mayur V, Łos Marek J

Abstract excerpt

Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. De-regulation of this pathway, i.e. by mutations may prevent the immune system from the removal of newly-formed tumor cells, and thus lead to tumor formation. The present study investigated the association between -1377 G/A (rs2234767) and -670 A/G (rs1800682) polymorphisms in Fas as well as single...

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Source

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Identifiers

PMID: 23326385
DOI: 10.1371/journal.pone.0053075
PMCID: PMC3543397

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional polymorphisms of FAS and FASL gene and risk of breast cancer - pilot study of 134 cases.PMID 23326385Read ↗

Quantitative assessment of the association between three polymorphisms in FAS and FASL gene and breast cancer risk.Semantic proximity Read ↗

Association of the polymorphisms in the Fas/FasL promoter regions with cancer susceptibility: a systematic review and meta-analysis of 52 studies.Semantic proximity Read ↗

Evaluation of the Effect of Menopausal Status and BMI on Polymorphisms in Fas/Fas L and the Risk of Breast Cancer.Semantic proximity Read ↗

Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.Semantic proximity Read ↗

Distinct role of the Fas rs1800682 and FasL rs763110 polymorphisms in determining the risk of breast cancer among Han Chinese females.Semantic proximity Read ↗

The diplotype Fas -1377A/-670G as a genetic marker to predict a lower risk of breast cancer in Chinese women.Semantic proximity Read ↗

FAS-1377 A/G polymorphism in breast cancer: a meta-analysis.Semantic proximity Read ↗

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FASL rs763110 polymorphism contributes to cancer risk: an updated meta-analysis involving 43,295 subjects.Semantic proximity Read ↗

Correlation between FAS single nucleotide polymorphisms and breast carcinoma susceptibility in Asia.Semantic proximity Read ↗

Fas cell surface death receptor/Fas ligand genetic variants in gastric cancer patients: A case-control study.Semantic proximity Read ↗

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