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Article

A helical capping motif in ShK toxin and its role in helix stabilization.

Biopolymers - 5 Apr 2001

Lanigan M D, Tudor J E, Pennington M W, Norton R S

Abstract excerpt

ShK toxin, a 35-residue polypeptide cross-linked by three disulfides, is a potent blocker of voltage-gated potassium channels and is of interest as a lead in the development of new immunosuppressant agents. ShK toxin contains two short stretches of alpha-helix, the first of which is preceded by a putative N-capping box encompassing residues Thr13 and Gln16. (1)H and (13)C NMR data support the presence of this...

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Identifiers

PMID: 11180055
DOI: 10.1002/1097-0282(20010405)58:4<422::AID-BIP1018>3.0.CO;2-T

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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