Article
Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma.
The Journal of investigative dermatology - 1 Feb 2001
Box N F, Duffy D L, Irving R E, Russell A, Chen W, Griffyths L R, Parsons P G, Green A C, Sturm R A
Abstract excerpt
MC1R gene variants have previously been associated with red hair and fair skin color, moreover skin ultraviolet sensitivity and a strong association with melanoma has been demonstrated for three variant alleles that are active in influencing pigmentation: Arg151Cys, Arg160Trp, and Asp294His. This study has confirmed these pigmentary associations with MC1R genotype in a collection of 220 individuals drawn from the...
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