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Article

Allelic association is increased by correlation of effective family size.

European journal of human genetics : EJHG - 1 Dec 2000

Austerlitz F, Heyer E

Abstract excerpt

In a previous study, we showed that the observation of high frequencies of certain inherited disorders in the population of Saguenay Lac Saint Jean (SLSJ) in Quebec can be explained in terms of the variance and the auto-correlation of effective family size (EFS) across generations. Correlated EFS, across generations, allows alleles introduced as a single copy to reach very high frequencies in about 12...

Topics

Alleles
Computer Simulation
Family Characteristics
Founder Effect
Genetic Linkage
Haplotypes
Humans
Likelihood Functions
Linkage Disequilibrium
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11175287
DOI: 10.1038/sj.ejhg.5200556

Genes

EFS

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