Article
Modelling the effects of penetrance and family size on rates of sporadic and familial disease.
Human heredity - 1 Jan 2011
Al-Chalabi Ammar, Lewis Cathryn M
Abstract excerpt
BACKGROUND/AIMS: Many complex diseases show a diversity of inheritance patterns ranging from familial disease, manifesting with autosomal dominant inheritance, through to simplex families in which only one person is affected, manifesting as apparently sporadic disease. The role of ascertainment bias in generating apparent patterns of inheritance is often overlooked. We therefore explored the role of two key...
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