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Article

Origin and mechanisms of non-disjunction In human autosomal trisomies

1 Feb 1998

Abstract excerpt

Chromosomal aneuploidy is one of the major causes of pregnancy wastage. In this review we summarize the knowledge about the origin and mechanisms of non-disjunction in human autosomal trisomies 8, 13, 15, 16, 18, and 21, accumulated during the last decade by using DNA polymorphism analysis. Maternal meiosis I non-disjunction is the most important single class, but chromosome-specific patterns exist. For the...

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PMID: 9557829
DOI: 10.1093/humrep/13.2.313

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