IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia.

doi:10.1111/his.15095

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Article

IDH1-mutated Crohn's disease-associated small bowel adenocarcinomas: Distinctive pathological features and association with MGMT methylation and serrated-type dysplasia.

Histopathology - 1 Feb 2024

Guerini Camilla, Furlan Daniela, Ferrario Giuseppina, Grillo Federica, Libera Laura, Arpa Giovanni, Klersy Catherine, Lenti Marco V, Riboni Roberta, Solcia Enrico, Fassan Matteo, Mastracci Luca, Ardizzone Sandro, Moens Annick, De Hertogh Gert, Ferrante Marc, Graham Rondell P, Sessa Fausto, Paulli Marco, Di Sabatino Antonio, Vanoli Alessandro

Abstract excerpt

AIMS: Patients with Crohn's disease (CrD) have an elevated risk for the development of small bowel adenocarcinomas (SBAs). Actionable isocitrate dehydrogenase 1 (IDH1) mutations have been reported to be more frequent in CrD-SBAs than in sporadic SBAs. The present study aimed to investigate the clinicopathological and immunophenotypical features, as well as methylation profiles, of IDH1-mutated CrD-SBAs. METHODS...

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PMID: 37988281
DOI: 10.1111/his.15095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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