Article
Intensity-dependent constitutional MLH1 promoter methylation leads to early onset of colorectal cancer by affecting both alleles.
Genes, chromosomes & cancer - 1 Mar 2011
Auclair Jessie, Vaissière Thomas, Desseigne Françoise, Lasset Christine, Bonadona Valérie, Giraud Sophie, Saurin Jean-Christophe, Joly Marie-Odile, Leroux Dominique, Faivre Laurence, Audoynaud Carole, Montmain Gilles, Ruano Eric, Herceg Zdenko, Puisieux Alain, Wang Qing
Abstract excerpt
Constitutional epimutation is one of the causes for MLH1 gene inactivation associated with hereditary non-polyposis colon cancer (HNPCC) syndrome. Here we investigate MLH1 promoter hypermethylation in 110 sporadic early-onset colorectal cancer patients. Variable levels of hypermethylation were detected in 55 patients (50%). Importantly a reduced MLH1 gene expression was found in patients with high-level...
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