Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA Topoisomerase II as the Target for the Anticancer Drug TOP-53: Mechanistic Basis for Drug Action

28 Dec 2000

Abstract excerpt

TOP-53 is a promising anticancer agent that displays high activity against non-small cell lung cancer in animal tumor models [Utsugi, T., et al. (1996) Cancer Res. 56, 2809-2814]. Compared to its parent compound, etoposide, TOP-53 is considerably more toxic to non-small cell lung cancer cells, is more active at generating chromosomal breaks, and displays improved cellular uptake and pharmacokinetics in animal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Synthesis and Biological Evaluation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11170388
DOI: 10.1021/bi0021838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA Topoisomerase II as the Target for the Anticancer Drug TOP-53: Mechanistic Basis for Drug ActionPMID 11170388Read ↗

DNA Topoisomerases as Targets for the Anticancer Drug TAS-103: Primary Cellular Target and DNA Cleavage EnhancementSemantic proximity Read ↗

Etoposide, Topoisomerase II and CancerSemantic proximity Read ↗

Etoposide: Discovery and Medicinal ChemistrySemantic proximity Read ↗

Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity.Semantic proximity Read ↗

Human DNA topoisomerase IIalpha-dependent DNA cleavage and yeast cell killing by anthracycline analogues.Semantic proximity Read ↗

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs.Semantic proximity Read ↗

Cell-based assays for identification of novel double-strand break-inducing agents.Semantic proximity Read ↗

Mechanism of action of DNA topoisomerase inhibitorsSemantic proximity Read ↗

Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.Semantic proximity Read ↗

Induction of Topoisomerase II-Mediated DNA Cleavage by a Protoberberine Alkaloid, BerberrubineSemantic proximity Read ↗

Retroviral expression of a mutant (Gly-533) human DNA topoisomerase I cDNA confers a dominant form of camptothecin resistance.Semantic proximity Read ↗

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.