Article
Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction.
Circulation - 27 Nov 2001
Topol E J, McCarthy J, Gabriel S, Moliterno D J, Rogers W J, Newby L K, Freedman M, Metivier J, Cannata R, O'Donnell C J, Kottke-Marchant K, Murugesan G, Plow E F, Stenina O, Daley G Q
Abstract excerpt
BACKGROUND: Recent advances in high-throughput genomics technology have expanded our ability to catalogue allelic variants in large sets of candidate genes related to premature coronary artery disease. METHODS AND RESULTS: A total of 398 families were identified in 15 participating medical centers; they fulfilled the criteria of myocardial infarction, revascularization, or a significant coronary artery lesion...
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