Article
Gender- and age-dependent relationships between the E-selectin S128R polymorphism and coronary artery calcification.
Journal of molecular medicine (Berlin, Germany) - 1 Jul 2001
Ellsworth D L, Bielak L F, Turner S T, Sheedy P F, Boerwinkle E, Peyser P A
Abstract excerpt
Development and progression of atherosclerosis involves recruitment and binding of circulating leukocytes to areas of inflammation within the vascular endothelium mediated by a diverse array of cellular adhesion molecules. A polymorphism in the endothelial-leukocyte adhesion molecule 1 (E-selectin) gene has been implicated in early-onset, angiographically defined, severe atherosclerotic disease because it...
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