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Large granular lymphocyte leukaemia is characterized by a clonal T‐cell receptor rearrangement in both memory and effector CD8<sup>+</sup> lymphocyte populations

1 Jan 2001

Abstract excerpt

Large granular lymphocyte (LGL) leukaemia is a disease with increased numbers of circulating granular lymphocytes and an increased percentage of clonally rearranged CD8(+)CD57(+) cells. To determine whether LGL cells are also found in other lymphocyte subsets, CD8(+) cells from 10 LGL patients were sorted into CD57(+) and CD57(-) fractions and analysed for clonality using a T-cell receptor gamma (TCR gamma)...

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PMID: 11167801
DOI: 10.1046/j.1365-2141.2001.02509.x

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