A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice.

doi:10.1006/dbio.1998.8905

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Article

A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice.

Developmental biology - 1 Jul 1998

Charng M J, Frenkel P A, Lin Q, Yamada M, Schwartz R J, Olson E N, Overbeek P, Schneider M D, Yumada M

Abstract excerpt

TGF beta family members are implicated in cardiac organogenesis, growth control, and positional information, including the direction of cardiac looping. However, genetic analysis of TGF beta signaling in mice has been confounded, in some cases, by noncardiac and generalized defects. Hence, deciph...

Topics

Activin Receptors, Type I
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA-Binding Proteins
Heart
Homeobox Protein Nkx-2.5
Homeodomain Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Morphogenesis

Mutation

Myocardium

Protein Serine-Threonine Kinases

Receptor, Transforming Growth Factor-beta Type I

Receptors, Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 9676193
DOI: 10.1006/dbio.1998.8905

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9676193-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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