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Article

A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice.

Developmental biology - 1 Jul 1998

Charng M J, Frenkel P A, Lin Q, Yamada M, Schwartz R J, Olson E N, Overbeek P, Schneider M D, Yumada M

Abstract excerpt

TGF beta family members are implicated in cardiac organogenesis, growth control, and positional information, including the direction of cardiac looping. However, genetic analysis of TGF beta signaling in mice has been confounded, in some cases, by noncardiac and generalized defects. Hence, deciphering TGF beta function in myocardium would benefit from cardiac-restricted mutations. We developed a constitutively...

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Identifiers

PMID: 9676193
DOI: 10.1006/dbio.1998.8905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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