Article
Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2005
Neri Simona, Gardini Alessandro, Facchini Andrea, Olivieri Fabiola, Franceschi Claudio, Ravaglia Giovanni, Mariani Erminia
Abstract excerpt
Age-related alterations of DNA repair could be involved in the accumulation of genetic damage with age. Few data suggest a possible alteration with age of the mismatch repair system, evidenced by the acquisition of microsatellite instability. We aimed to point out a possible implication of this repair system in the accumulation of genetic damage with age. Peripheral blood cell DNA from 226 participants, 110 young...
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