Molecular and cytogenetic alterations in early stage of carcinogenesis of human lung.

doi:10.1016/s0304-3835(00)00641-8

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Article

Molecular and cytogenetic alterations in early stage of carcinogenesis of human lung.

Cancer letters - 1 Jan 2001

Cheng S, Gao Y, Dong X, Lu Y, An Q, Tong T, Wang Y

Abstract excerpt

In an attempt to reveal the genetic and epigenetic abnormalities in early stage of carcinogenesis of human lung cancer, a human bronchial epithelial cell line was immortalized by transfection with the Simian virus early region genes (SV40T); the biological features of the stable transfected cells were compared to human non-small cell lung cancer (NSCLC) specimens. The immortalized bronchial epithelial cells did...

Topics

Animals
Carcinoma, Non-Small-Cell Lung
Cell Line, Transformed
Chromosome Aberrations
Cyclin-Dependent Kinase Inhibitor p16
Cytogenetic Analysis
Gene Expression Regulation, Neoplastic
Genes, myc
Humans
Lung Neoplasms
Mutation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 11164184
DOI: 10.1016/s0304-3835(00)00641-8

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