Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease.

doi:10.1002/ana.410440207

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Article

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease.

Annals of neurology - 1 Aug 1998

Gu M, Cooper J M, Taanman J W, Schapira A H

Abstract excerpt

Several groups have identified mitochondrial complex I deficiency in Parkinson's disease (PD) substantia nigra and in platelets. A search for any mitochondrial DNA (mtDNA) mutation underlying this defect has not yet produced any consistent result. We have made use of a mtDNA-less (p0) cell line t...

Topics

Benzimidazoles
Blood Platelets
Carbocyanines
Clone Cells
DNA, Mitochondrial
Electron Transport
Fluorescent Dyes
Humans
Immunohistochemistry
Mitochondria
Mutation
Parkinson Disease
Platelet Membrane Glycoproteins
Polymerase Chain Reaction

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