Article
Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease.
Annals of neurology - 1 Aug 1998
Gu M, Cooper J M, Taanman J W, Schapira A H
Abstract excerpt
Several groups have identified mitochondrial complex I deficiency in Parkinson's disease (PD) substantia nigra and in platelets. A search for any mitochondrial DNA (mtDNA) mutation underlying this defect has not yet produced any consistent result. We have made use of a mtDNA-less (p0) cell line to determine if the complex I deficiency follows the genomic transplantation of platelet mtDNA. From a preselected group...
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