Article
Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family.
Annals of neurology - 1 Dec 1998
Swerdlow R H, Parks J K, Davis J N, Cassarino D S, Trimmer P A, Currie L J, Dougherty J, Bridges W S, Bennett J P, Wooten G F, Parker W D
Abstract excerpt
Recent data suggesting complex I dysfunction in Parkinson's disease (PD) arises from mitochondrial DNA (mtDNA) mutation does not conclusively answer whether the responsible genetic lesion is inherited (primary) or somatic (secondary). To address this question, we identified a family in which multiple members over three generations are affected with PD through exclusively maternal lines. Cytoplasmic hybrids...
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