Article
Terminal sialylation is altered in airway cells with impaired CFTR-mediated chloride transport.
American journal of physiology. Lung cellular and molecular physiology - 1 Mar 2001
Kube D, Adams L, Perez A, Davis P B
Abstract excerpt
Reduced terminal sialylation at the surface of airway epithelial cells from patients with cystic fibrosis may predispose them to bacterial infection. To determine whether a lack of chloride transport or misprocessing of mutant cystic fibrosis transmembrane conductance regulator (CFTR) is critical for the alterations in glycosylation, we studied a normal human tracheal epithelial cell line (9/HTEo(-)) transfected...
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