Article
Opposing actions of prostaglandins and oxytocin determine the onset of murine labor.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Gross G A, Imamura T, Luedke C, Vogt S K, Olson L M, Nelson D M, Sadovsky Y, Muglia L J
Abstract excerpt
Prostaglandins (PGs) have been recently proven essential for parturition in mice. To dissect the contributions of the two cyclooxygenase (COX) isoforms to the synthesis of PGs during pregnancy, we have characterized the parturition phenotype of COX-1-deficient mice. We find that mice with targete...
Topics
- Animals
- Corpus Luteum
- Cyclooxygenase 1
- Dinoprost
- Embryo Transfer
- Female
- Gene Expression
- In Situ Hybridization
- Isoenzymes
- Labor Onset
- Male
- Membrane Proteins