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Article

Opposing actions of prostaglandins and oxytocin determine the onset of murine labor.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

Gross G A, Imamura T, Luedke C, Vogt S K, Olson L M, Nelson D M, Sadovsky Y, Muglia L J

Abstract excerpt

Prostaglandins (PGs) have been recently proven essential for parturition in mice. To dissect the contributions of the two cyclooxygenase (COX) isoforms to the synthesis of PGs during pregnancy, we have characterized the parturition phenotype of COX-1-deficient mice. We find that mice with targeted disruption of the COX-1 gene have delayed parturition resulting in neonatal death. Results of matings of...

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Identifiers

PMID: 9751758
DOI: 10.1073/pnas.95.20.11875
PMCID: PMC21733

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