Article
The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Feb 2001
Rau H, Braun J, Donner H, Seissler J, Siegmund T, Usadel K H, Badenhoop K
Abstract excerpt
Several studies have demonstrated an association of CTLA4 (IDDM12) alanine-17 with type 1 diabetes, but CTLA4 variants have not yet been investigated in type 2 diabetes. The CTLA4 exon 1 polymorphism (49 A/G) was analyzed in 300 Caucasian patients with type 2 diabetes and 466 healthy controls. All patients were negative for glutamate decarboxylase and islet cell antibodies. CTLA4 alleles were defined by PCR,...
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