Article
Pituitary response to luteinizing hormone-releasing hormone in women with variant luteinizing hormone.
European journal of endocrinology - 1 Sept 2000
Takahashi K, Kurioka H, Ozaki T, Kanasaki H, Miyazaki K, Karino K
Abstract excerpt
OBJECTIVE: To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN: Clinical study. PATIENTS: We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant gene, 17 heterozygotes, and 20 homozygotes for the wild type). All women had normal ovulatory...
Topics
- Adult
- DNA
- Female
- Gonadotropin-Releasing Hormone
- Humans
- Immunoassay
- Luteinizing Hormone
- Mutation
- Pituitary Gland
- Reverse Transcriptase Polymerase Chain Reaction
