Article
Recurrent genomic alterations in benign and malignant pheochromocytomas and paragangliomas revealed by whole-genome array comparative genomic hybridization analysis.
Endocrine-related cancer - 1 Sept 2010
Sandgren Johanna, Diaz de Ståhl Teresita, Andersson Robin, Menzel Uwe, Piotrowski Arkadiusz, Nord Helena, Bäckdahl Martin, Kiss Nimrod B, Brauckhoff Michael, Komorowski Jan, Dralle Henning, Hessman Ola, Larsson Catharina, Akerström Göran, Bruder Carl, Dumanski Jan P, Westin Gunnar
Abstract excerpt
Pheochromocytomas and abdominal paragangliomas are adrenal and extra-adrenal catecholamine-producing tumours. They arise due to heritable cancer syndromes, or more frequently occur sporadically due to an unknown genetic cause. The majority of cases are benign, but malignant tumours are observed. Previous comparative genomic hybridization (CGH) and loss of heterozygosity studies have shown frequent deletions of...
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