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Article

Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1

1 Dec 2000

Abstract excerpt

Pheochromocytomas arise sporadically and as a component tumor of the inherited cancer syndromes von Hippel-Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN 2), and type 1 neurofibromatosis. Germline mutations of the VHL tumor suppressor gene (VHL) are responsible for VHL, and germline RET protooncogene mutations are associated with MEN 2. The present study was conducted to examine a large series of...

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Identifiers

PMID: 11134110
DOI: 10.1210/jcem.85.12.7015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1PMID 11134110Read ↗

Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas.Semantic proximity Read ↗

Sporadic and familial pheochromocytomas are associated with loss of at least two discrete intervals on chromosome 1p.Semantic proximity Read ↗

Mutations in the VHL tumor suppressor gene and associated lesions in families with von Hippel-Lindau disease from central Europe.Semantic proximity Read ↗

Sporadic Pheochromocytomas Are Rarely Associated with Germline Mutations in the<i>vhl</i>Tumor Suppressor Gene or the<i>ret</i>Protooncogene<sup>1</sup>Semantic proximity Read ↗

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.Semantic proximity Read ↗

Clinical and genetic characterization of pheochromocytoma in von Hippel-Lindau families: comparison with sporadic pheochromocytoma gives insight into natural history of pheochromocytoma.Semantic proximity Read ↗

Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.Semantic proximity Read ↗

Genetic aspects of pheochromocytoma.Semantic proximity Read ↗

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.Semantic proximity Read ↗

Loss of heterozygosity suggests multiple genetic alterations in pheochromocytomas and medullary thyroid carcinomas.Semantic proximity Read ↗

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.Semantic proximity Read ↗

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype.Semantic proximity Read ↗

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