Article
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2009
Liu Yang, Wang Yan, Zhang Yong, Miao Yuan, Zhao Yue, Zhang Peng-Xin, Jiang Gui-Yang, Zhang Jun-Yi, Han Yang, Lin Xu-Yong, Yang Lian-He, Li Qing-Chang, Zhao Chen, Wang En-Hua
Abstract excerpt
Studies on a variety of cell lines have shown that p120-catenin can directly regulate the stability of E-cadherin complexes and control the activity of small GTPases to influence cell adhesion. Despite this data, clinical studies of human solid tumors have not been reported to investigate these protein interactions. To explore the correlation between p120-catenin, E-cadherin, and small GTPases in human lung...
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