Article
Early changes in quasispecies repertoire in HIV-infected infants: correlation with disease progression.
AIDS research and human retroviruses - 10 Dec 2000
Essajee S M, Pollack H, Rochford G, Oransky I, Krasinski K, Borkowsky W
Abstract excerpt
The evolution of HIV-1 quasispecies in patients during the first year of life was investigated in 10 vertically infected infants, using heteroduplex analysis of the V3-V5 region of env. Four subjects, who showed little viral evolution during the period of the study, had rapid progression of disease and early loss of CD4(+) cells. The remaining six subjects, who were slow progressors, evolved new viral variants...
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