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Article

Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.

Neurobiology of disease - 1 Jun 2001

Schilling G, Jinnah H A, Gonzales V, Coonfield M L, Kim Y, Wood J D, Price D L, Li X J, Jenkins N, Copeland N, Moran T, Ross C A, Borchelt D R

Abstract excerpt

Huntington's disease (HD) and Dentatorubral and pallidoluysian atrophy (DRPLA) are autosomal dominant, neurodegenerative disorders caused by the expansion of polyglutamine tracts in their respective proteins, huntingtin and atrophin-1. We have previously generated mouse models of these disorders, using transgenes expressed via the prion protein promoter. Here, we report the first direct comparison of...

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Identifiers

PMID: 11442350
DOI: 10.1006/nbdi.2001.0385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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