Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

doi:10.1073/pnas.93.22.12304

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Article

Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996

Scott S V, Hefner-Gravink A, Morano K A, Noda T, Ohsumi Y, Klionsky D J

Abstract excerpt

The vacuolar protein aminopeptidase I (API) uses a novel cytoplasm-to-vacuole targeting (Cvt) pathway. Complementation analysis of yeast mutants defective for cytoplasm-to-vacuole protein targeting (cvt) and autophagy (apg) revealed seven overlapping complementation groups between these two sets...

Topics

Aminopeptidases
Autophagy
Cytoplasm
Genetic Complementation Test
Genotype
Kinetics
Nitrogen
Phenotype
Proton-Translocating ATPases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Vacuolar Proton-Translocating ATPases
Vacuoles

Source

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Identifiers

PMID: 8901576
DOI: 10.1073/pnas.93.22.12304
PMCID: PMC37986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8901576-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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