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Article

Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families.

Diabetologia - 1 Dec 2000

Delplanque J, Barat-Houari M, Dina C, Gallina P, Clément K, Guy-Grand B, Vasseur F, Boutin P, Froguel P

Abstract excerpt

AIMS/HYPOTHESIS: The region 2p21-23, containing the proopiomelanocortin gene (POMC), was reported to be linked to leptin concentrations in Mexican-American, French and African-American cohorts. A polyhormone peptide, POMC is expressed in brain, gut, placenta and pancreas. The POMC mutations are responsible for rare cases of early-onset obesity. Thus we examined the contribution of the POMC locus to obesity in...

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Source

Identifiers

PMID: 11151766
DOI: 10.1007/s001250051568

Genes

POMC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families.PMID 11151766Read ↗

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A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10.Semantic proximity Read ↗

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Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain.Semantic proximity Read ↗

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