Article
Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study.
Diabetes - 1 Aug 2005
Baker Michelle, Gaukrodger Nicole, Mayosi Bongani M, Imrie Helen, Farrall Martin, Watkins Hugh, Connell John M C, Avery Peter J, Keavney Bernard
Abstract excerpt
Rare mutations in the proopiomelanocortin (POMC) gene cause severe early-onset childhood obesity. However, it is unknown whether common variants in POMC are responsible for variation in body weight or fat distribution within the commonly observed range in the population. We tested for association between three polymorphisms spanning the POMC gene and obesity phenotypes in 1,428 members of 248 families. There was...
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