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Article

Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC.

The Journal of clinical endocrinology and metabolism - 1 Sept 1999

Hixson J E, Almasy L, Cole S, Birnbaum S, Mitchell B D, Mahaney M C, Stern M P, MacCluer J W, Blangero J, Comuzzie A G

Abstract excerpt

We previously reported that our genome-scanning initiative had detected a highly significant linkage (log odds ratio = 4.95; P = 9 x 10(-7)) between a quantitative trait locus (QTL) on chromosome 2 and leptin levels in Mexican American families. We now have typed additional microsatellite markers in this region, increasing this log odds ratio score to 7.46 (P = 2 x 10(-9)). This region of chromosome 2 contains a...

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Source

Identifiers

PMID: 10487685
DOI: 10.1210/jcem.84.9.5951

Genes

POMC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene, POMC.PMID 10487685Read ↗

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Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic diseaseSemantic proximity Read ↗

60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.Semantic proximity Read ↗

A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10.Semantic proximity Read ↗

Association study of POMC variants with body composition measures and nutrient choice.Semantic proximity Read ↗

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