Article
Estimating the selective advantage of mutant p53 tumour cells to repeated rounds of hypoxia.
Bulletin of mathematical biology - 1 Jan 2001
Gammack D, Byrne H M, Lewis C E
Abstract excerpt
The tumour suppressor gene, p53, plays an important role in tumour development. Under low levels of oxygen (hypoxia), cells expressing wild-type p53 undergo programmed cell death (apoptosis), whereas cells expressing mutations in the p53 gene may survive and express angiogenic growth factors that...
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