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Article

Blood vessel tortuosity selects against evolution of aggressive tumor cells in confined tissue environments: A modeling approach.

PLoS computational biology - 1 Jul 2017

Szabó András, Merks Roeland M H

Abstract excerpt

Cancer is a disease of cellular regulation, often initiated by genetic mutation within cells, and leading to a heterogeneous cell population within tissues. In the competition for nutrients and growth space within the tumors the phenotype of each cell determines its success. Selection in this process is imposed by both the microenvironment (neighboring cells, extracellular matrix, and diffusing substances), and...

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PMID: 28715420
DOI: 10.1371/journal.pcbi.1005635
PMCID: PMC5536454

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