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Article

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

Molecular biology of the cell - 1 Apr 2008

Morito Daisuke, Hirao Kazuyoshi, Oda Yukako, Hosokawa Nobuko, Tokunaga Fuminori, Cyr Douglas M, Tanaka Keiji, Iwai Kazuhiro, Nagata Kazuhiro

Abstract excerpt

Misfolded or improperly assembled proteins in the endoplasmic reticulum (ER) are exported into the cytosol and degraded via the ubiquitin-proteasome pathway, a process termed ER-associated degradation (ERAD). Saccharomyces cerevisiae Hrd1p/Der3p is an ER membrane-spanning ubiquitin ligase that participates in ERAD of the cystic fibrosis transmembrane conductance regulator (CFTR) when CFTR is exogenously expressed...

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Source

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Identifiers

PMID: 18216283
DOI: 10.1091/mbc.e07-06-0601
PMCID: PMC2291415

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.PMID 18216283Read ↗

Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants.Semantic proximity Read ↗

A role for mammalian Ubc6 homologues in ER-associated protein degradation.Semantic proximity Read ↗

Cystic fibrosis transmembrane conductance regulator degradation depends on the lectins Htm1p/EDEM and the Cdc48 protein complex in yeast.Semantic proximity Read ↗

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.Semantic proximity Read ↗

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).Semantic proximity Read ↗

The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins.Semantic proximity Read ↗

Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin.Semantic proximity Read ↗

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation.Semantic proximity Read ↗

The multiple ubiquitination mechanisms in CFTR peripheral quality control.Semantic proximity Read ↗

The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508Semantic proximity Read ↗

Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis.Semantic proximity Read ↗

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.Semantic proximity Read ↗

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