Article
Sandwich ELISA for the measurement of Apo-E4 levels in serum and the estimation of the allelic status of Apo-E4 isoforms.
Journal of clinical laboratory analysis - 1 Jan 2000
Uchida Y, Ito S, Nukina N
Abstract excerpt
Apolipoprotein-E (Apo-E) isoforms, especially theApo-E4 isoform, are considered to be genetic risk factors for familial as well as sporadic Alzheimer's disease (AD). Using monoclonal antibodies specific for Apo-E4 (MAb412-1-7) and Apo-E (LZ18), we established a sandwich ELISA for the measurement of Apo-E4 levels in serum. Total Apo-E also was determined by sandwich ELISA with a second pair of monoclonal...
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