Article
Counting alleles reveals a connection between chromosome 18q loss and vascular invasion.
Nature biotechnology - 1 Jan 2001
Zhou W, Galizia G, Lieto E, Goodman S N, Romans K E, Kinzler K W, Vogelstein B, Choti M A, Montgomery E A
Abstract excerpt
The analysis of loss of heterozygosity (LOH) is perhaps the most widely used technique in cancer genetics. In primary tumors, however, the analysis of LOH is fraught with technical problems that have limited its reproducibility and interpretation. In particular, tumors are mixtures of neoplastic and nonneoplastic cells, and the DNA from the nonneoplastic cells can mask LOH. We here describe a new experimental...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.