Article
Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures.
The Journal of biological chemistry - 9 Mar 2001
Kawai H, Allende M L, Wada R, Kono M, Sango K, Deng C, Miyakawa T, Crawley J N, Werth N, Bierfreund U, Sandhoff K, Proia R L
Abstract excerpt
Gangliosides are a family of glycosphingolipids that contain sialic acid. Although they are abundant on neuronal cell membranes, their precise functions and importance in the central nervous system (CNS) remain largely undefined. We have disrupted the gene encoding GD3 synthase (GD3S), a sialyltransferase expressed in the CNS that is responsible for the synthesis of b-series gangliosides. GD3S-/- mice, even with...
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