Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy.

doi:10.1007/s002510000245

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Article

Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy.

Immunogenetics - 1 Nov 2000

Miyagawa T, Hohjoh H, Honda Y, Juji T, Tokunaga K

Abstract excerpt

We report on a study performed to determine a boundary of the region with the potential to contribute to the predisposition to human narcolepsy (the susceptibility region) in the human leukocyte antigen (HLA) region. We investigated a Japanese narcolepsy family, in which a de novo chromosomal recombination occurred between the HLA-DRB1 and HLA-B genes in the proband. The recombinant chromosome carrying...

Topics

Female
Genetic Predisposition to Disease
HLA Antigens
HLA-B Antigens
HLA-DR Antigens
HLA-DRB1 Chains
Haplotypes
Humans
Male
Microsatellite Repeats
Narcolepsy
Pedigree
Polymorphism, Genetic
Proto-Oncogene Proteins
Receptor, Notch4
Receptors, Cell Surface
Receptors, Notch
Recombination, Genetic

Source

Open in PubMed

Identifiers

PMID: 11132147
DOI: 10.1007/s002510000245

Genes

PPT2

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