Article
Mechanisms mediating the effects of IL-3 gene expression on tumor growth.
Journal of leukocyte biology - 1 Dec 2000
Wu Y Z, Hong J H, Huang H H, Dougherty G J, McBride W H, Chiang C S
Abstract excerpt
IL-3 gene expression within tumors leads to host-cell infiltration, particularly by macrophages, slower tumor growth, and enhanced immunogenicity. Surprisingly, tumor-associated macrophages (TAMs) from within FSAN-JmIL3 tumors had decreased expression of TNF-alpha and iNOS. On short-term culture, TAMs from FSAN-JmIL3 tumors regained their capacity to produce TNF-alpha and NO, indicating that they were primed in...
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