Article
In situ detection of specific p53 mutations in cultured cells using the amplification refractory mutation system polymerase chain reaction.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 2000
Low E O, Gibbins J R, Walker D M
Abstract excerpt
Accurate molecular detection of genetic mutations involved in tumorigenesis has been based predominantly on analysis of extracted DNA, but this does not provide detailed information on the location, number, type or clonal distribution of mutated cells and their precise anatomic location and clonal distribution. This study has used a sensitive and specific application of the amplification refractory mutation...
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