Article
Age-related mitochondrial DNA mutations in the human larynx.
The Laryngoscope - 1 Dec 2000
Manaligod J M, Milam M, Hill S A, Sanders T, Skaggs J, Smith R J
Abstract excerpt
OBJECTIVE: To determine whether age-related mitochondrial DNA mutations occur in the human larynx. STUDY DESIGN: Genetic study of cadaveric larynx specimens. METHODS: Vocal fold mucosa, thyroarytenoid muscle, and cricoarytenoidjoint tissue were harvested from 13 fresh postmortem larynges (age range, 2 d-82 y). DNA was extracted from each sample, and the polymerase chain reaction (PCR) was used to amplify a target...
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