Article
Oxidation-Specific Epitopes (OSEs) Dominate the B Cell Response in Murine Polymicrobial Sepsis.
Frontiers in immunology - 1 Jan 2020
Nicolai Oliver, Pötschke Christian, Raafat Dina, van der Linde Julia, Quosdorf Sandra, Laqua Anna, Heidecke Claus-Dieter, Berek Claudia, Darisipudi Murthy N, Binder Christoph J, Bröker Barbara M
Abstract excerpt
In murine abdominal sepsis by colon ascendens stent peritonitis (CASP), a strong increase in serum IgM and IgG antibodies was observed, which reached maximum values 14 days following sepsis induction. The specificity of this antibody response was studied in serum and at the single cell level using a broad panel of bacterial, sepsis-unrelated as well as self-antigens. Whereas an antibacterial IgM/IgG response was...
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