Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The identification of a novel T cell activation state controlled by a diabetogenic gene.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2001

Moore J K, Scheinman R I, Bellgrau D

Abstract excerpt

The cyclin-dependent kinase inhibitor p27(kip) regulates the cell cycle at the G(1)-S phase restriction point. S phase entry and cell cycle commitment in peripheral T cells requires p27(kip) degradation, normally initiated by the receipt of costimulatory signals such as those provided by B7.1 or IL-2. We have previously reported that T cells from BioBreeding (BB)-diabetes-prone (DP) rats exhibit decreased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p27
Share to Lymphopenia
Share to Proliferating Cell Nuclear Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Rats, Inbred BB

Share to Rats, Inbred Lew

Share to Thy-1 Antigens

Source

Identifiers

PMID: 11123298
DOI: 10.4049/jimmunol.166.1.241

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The identification of a novel T cell activation state controlled by a diabetogenic gene.PMID 11123298Read ↗

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytesSemantic proximity Read ↗

Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cellsSemantic proximity Read ↗

Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes.Semantic proximity Read ↗

p27 Regulates the transition of beta-cells from quiescence to proliferation.Semantic proximity Read ↗

Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.Semantic proximity Read ↗

The growth suppressor p27 <sup>Kip1</sup> protects against diet‐induced atherosclerosisSemantic proximity Read ↗

The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision.Semantic proximity Read ↗

Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.Semantic proximity Read ↗

G1 arrest and high expression of cyclin kinase and apoptosis inhibitors in accumulated activated/memory phenotype CD4+ cells of older lupus mice.Semantic proximity Read ↗

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).Semantic proximity Read ↗

T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes.Semantic proximity Read ↗

p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.