Article
A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2001
Resch W, Parkin N, Stuelke E L, Watkins T, Swanstrom R
Abstract excerpt
Rapidly evolving entities, such as viruses, can undergo complex genetic changes in the face of strong selective pressure. We have developed a modified heteroduplex tracking assay (HTA) capable of detecting the presence of single, specific mutations or sets of linked mutations. The initial application of this approach, termed multiple-site-specific (MSS) HTA, was directed toward the detection of mutations in the...
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