Article
Human immunodeficiency virus type 1 evolution in vivo tracked by DNA heteroduplex mobility assays.
Journal of virology - 1 Oct 1994
Delwart E L, Sheppard H W, Walker B D, Goudsmit J, Mullins J I
Abstract excerpt
High mutation rates and strong selective pressures imposed on human immunodeficiency viruses in vivo result in the formation of pools of genetic variants known as quasispecies. DNA heteroduplex mobility and tracking analyses were used to monitor the generation of HIV sequence diversity, to estima...
Topics
- Acquired Immunodeficiency Syndrome
- Base Sequence
- Biological Evolution
- DNA Primers
- DNA, Viral
- Electrophoresis, Polyacrylamide Gel
- Follow-Up Studies
- Genes, env
- HIV-1
- Homosexuality
- Humans
- Lymphocytes
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Heteroduplexes
- Polymerase Chain Reaction
- Proviruses