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Article

Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assay.

Journal of virology - 1 Jul 2004

Kapoor Amit, Jones Morris, Shafer R W, Rhee Soo-Yon, Kazanjian Powel, Delwart Eric L

Abstract excerpt

Drug-resistant viruses may be present as minority variants during early treatment failures or following discontinuation of failed antiretroviral regimens. A limitation of the traditional direct PCR population sequencing method is its inability to detect human immunodeficiency virus type 1 (HIV-1) variants present at frequencies lower than 20%. A drug resistance genotyping assay based on the isolation and DNA...

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Identifiers

PMID: 15194787
DOI: 10.1128/JVI.78.13.7112-7123.2004
PMCID: PMC421662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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