Article
Energy landscape theory for Alzheimer's amyloid beta-peptide fibril elongation.
Proteins - 1 Feb 2001
Massi F, Straub J E
Abstract excerpt
Recent experiments on the kinetics of deposition and fibril elongation of the Alzheimer's beta-amyloid peptide on preexisting fibrils are analyzed. A mechanism is developed based on the dock-and-lock scheme recently proposed by Maggio and coworkers to organize their experimental observations of the kinetics of deposition of beta-peptide on preexisting amyloid fibrils and deposits. Our mechanism includes channels...
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