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Article

The Levinthal Problem in Amyloid Aggregation: Sampling of a Flat Reaction Space.

The journal of physical chemistry. B - 23 Feb 2017

Jia Zhiguang, Beugelsdijk Alex, Chen Jianhan, Schmit Jeremy D

Abstract excerpt

The formation of amyloid fibrils has been associated with many neurodegenerative disorders, yet the mechanism of aggregation remains elusive, partly because aggregation time scales are too long to probe with atomistic simulations. A microscopic theory of fibril elongation was recently developed that could recapitulate experimental results with respect to the effects of temperature, denaturants, and protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28129689
DOI: 10.1021/acs.jpcb.7b00253
PMCID: PMC5573152

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