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Article

Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.

Journal of virology - 1 Jan 2001

Van P L, Yim K W, Jin D Y, Dapolito G, Kurimasa A, Jeang K T

Abstract excerpt

Recent evidence from several investigators suggest that the human T-cell leukemia virus type 1 Tax oncoprotein represses the transcriptional activity of the tumor suppressor protein, p53. An examination of published findings reveals serious controversy as to the mechanism(s) utilized by Tax to inhibit p53 activity and whether the same mechanism is used by Tax in adherent and suspension cells. Here, we have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11119608
DOI: 10.1128/JVI.75.1.396-407.2001
PMCID: PMC113932

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53.PMID 11119608Read ↗

Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300.Semantic proximity Read ↗

Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.Semantic proximity Read ↗

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Semantic proximity Read ↗

Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Semantic proximity Read ↗

Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.Semantic proximity Read ↗

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.Semantic proximity Read ↗

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Paradoxical effects of a stress signal on pro- and anti-apoptotic machinery in HTLV-1 Tax expressing cells.Semantic proximity Read ↗

Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression.Semantic proximity Read ↗

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.Semantic proximity Read ↗

Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.Semantic proximity Read ↗

Activation of I-kappaB kinase by the HTLV type 1 Tax protein: mechanistic insights into the adaptor function of IKKgamma.Semantic proximity Read ↗

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