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Article

Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.

Virology - 30 Sept 2008

Zhang Jing, Yamada Osamu, Kawagishi Kenji, Araki Hiromasa, Yamaoka Shoji, Hattori Toshio, Shimotohno Kunitada

Abstract excerpt

We describe here Tax protein of human T-cell leukemia virus type 1 (HTLV-1) as an interferon (IFN)-alpha antagonist counteracting the transactivation function of IFN-stimulated gene factor 3 (ISGF3). Co-expression of Tax, but not the Tax mutant unable to bind to CBP, significantly inhibited the reporter gene expression directed by IFN-stimulated regulatory elements, despite that the formation of DNA-binding ISGF3...

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Source

Identifiers

PMID: 18678383
DOI: 10.1016/j.virol.2008.06.035

Genes

STAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.PMID 18678383Read ↗

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